Solvolysis of the Tumor-Inhibiting Ru(III)-Complex trans-Tetrachlorobis(Indazole)Ruthenate(III)

摘要

The ruthenium(III) complex Hlnd trans-[RuCl4,(ind)2], with two trans-standing indazole (ind)ligands bound to ruthenium via nitrogen, shows remarkable activity in different tumor modelsin vitro and in vivo. The solvolysis of the complex trans-[RuCl4,(ind)2]- has been investigated by means of spectroscopic techniques (UV/vis, NMR)in different solvents. We investigated theindazolium as well as the sodium salt, the latter showing improved solubility in water. Inaqueous acetonitrile and ethanol the solvolysis results in one main solvento complex. Thehydrolysis of the complex is more complicated and depends on the pH of the solution as wellas on the buffer system.